An Overview of Neuroprotective Mechanism of Methylene Blue

Duration: 28:25

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2 Comments

michael@*.com

Apr 19 2023, 5:27 pm

I use a powdered form of USP grade MB from cztl.bz (no connection with them). You can create whatever concentration you need, typical: 0.1% (w/v) up to 2.0% (w/v).

lkrzs@*.com

Mar 19 2023, 7:12 pm

What happened to the youtube videos?

Animal studies have demonstrated the neuroprotective role of methylene blue especially when administered within an hour of transient ischemic insult of the neurons. Methylene blue is antioxidant, anti-inflammatory, and induces autophagy while reducing apoptosis. Let's review its mechanisms.

Contraindications: https://www.rxlist.com/consumer_provayblue_methylene_blue/drugs-condition.htm

The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core | PLOS ONE https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131929

AMPK - Legere Pharmaceuticals https://www.legerepharm.com/ampk/

Schematic illustration of the mTOR signaling pathway. AMPK indicates... | Download Scientific Diagram https://www.researchgate.net/figure/Schematic-illustration-of-the-mTOR-signaling-pathway-AMPK-indicates-AMP-activated_fig1_228089413

Model of the AMPK and mTOR signaling network in mammalian cells. AMPK... | Download Scientific Diagram https://www.researchgate.net/figure/Model-of-the-AMPK-and-mTOR-signaling-network-in-mammalian-cells-AMPK-inhibits-mTOR_fig1_221865491

Frontiers | Protection against neurodegeneration with low-dose methylene blue and near-infrared light https://www.frontiersin.org/articles/10.3389/fncel.2015.00179/full

Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation | Translational Neurodegeneration | Full Text https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-020-00197-z

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Dr. Mobeen Syed

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